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News in Brief June 23rd, 2014

Effect of Diet or Diet plus Physical Activity versus Usual Care on Inflammatory Markers in Patients with newly diagnosed Type 2 Diabetes: The Early ACTivity In Diabetes (ACTID) randomized controlled Trial. Thompson D, Walhin JP, Batterham AM, Stokes KA, Cooper AR, Andrews RC. J Am Heart Assoc. 2014 May 8;3(3):e000828


In patients who lost 5 to 10% of their weight after dieting (combined or not with physical exercise) as soon as type 2 diabetes was diagnosed, the inflammatory marker levels (the CRP were 20% lower than in the Usual Care group after 6 months) and the cardiovascular risk factors (sICAM-1) improved considerably. Physical activity was not found in this study to yield any additional benefits to those of diet.



Timing of food intake and obesity: A novel association. Garaulet M, Gómez-Abellán P. Physiol Behav. 2014 Jan 24. pii: S0031-9384(14)00003-1.


After previously establishing that the timing of the main meal and the distribution of the calorie input during the day can affect dieting patients’ weight loss, the authors present new findings here which suggest that adipous tissues such as those in the stomach, intestine, pancreas and liver also obey a biological clock, which determines the times at which fat is  accumulated or mobilised. 



Early-treatment weight loss predicts 6-month weight loss in women with obesity and depression: implications for stepped care. Waring ME, Schneider KL, Appelhans BM, Busch AM, Whited MC, Rodrigues S, Lemon SC, Pagoto SL. J Psychosom Res. 2014 May;76(5):394-9.


The results of this study on 75 depressed obese women show that women who lose 450g per week after dieting for 2 weeks are 2.5 times more likely than others to lose at least 5% of their weight after dieting for 6 months. They also suggest that the intensity of the diet should be quickly increased among those who have difficulty in losing weight. 



Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial. Imayama I1, Alfano CM, Mason C, Wang C, Duggan C, Campbell KL, Kong A, Foster-Schubert KE, Blackburn GL, Wang CY, McTiernan A. Prev Med. 2013 Nov;57(5):525-32.


In this study on depressed obese women, neither the women’s compliance with the diet prescribed (daily intake : 1200 to 2000 kcal) nor their weight loss (in terms of body weight, waist circumference and percentage body fat) differed between the group under antidepressive treatment and those taking no medication. The group in which dieting was combined with physical exercise obtained the best results.



Impact of obesity and weight loss on cardiac performance and morphology in adults. Alpert MA, Omran J, Mehra A, Ardhanari S. Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):391-400.


Obesity and its effects on health (obstructive sleep apnea, metabolic and neuro-hormonal anomalies) are liable to have detrimental effects on patients’ vascular performances and cardiac morphology. After describing these changes, the authors suggest that it may be possible to reverse 

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